Regarding potential targets for targeted treatment of endometrial cancer (KRAS, PIK3CA, MLH1, MSH6, POLE, PTEN), relevant genomic changes were also detected in the supernatant and sediment of vaginal lavage fluid (Figure 4B), and these genomic changes were more pronounced in the supernatant of vaginal lavage fluid. This evidence concerns the gene PIK3CA and endometrial cancer.