The results of the multivariable logistic regression model indicate that being female is a protective factor against the progression of liver cirrhosis to hepatocellular carcinoma (OR = 0.532, OR 95% CI = 0.297-0.952); Hepatitis B, elevated total cholesterol, and reduced antithrombin III activity were identified as risk factors for the progression of cirrhosis to malignant liver tumours (OR = 4.080, OR 95% CI = 2.443–6.814, OR = 2.308, OR 95% CI = 1.132–4.707, OR = 2.982, OR 95% CI = 1.389–6.402) (P < 0.05), as shown in Table 2. The gene discussed is SERPINC1; the disease is liver cancer.