AR and posterior cortical atrophy: Canonical AR signaling consists of AR binding via its DNA binding domain (DBD) to androgen response elements (ARE) at promoters or enhancers of target genes that are widely known to be essential in prostate growth and development, as well as in PCa progression, such as KLK2, KLK3 (PSA), NKX3.1, TMPRSS2, FKBP5, and others (8, 9).