NFE2L2 and neoplasm: As a nuclear transport protein, KPNA2 regulates oxidative stress and ferroptosis pathways by mediating the nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) in non-small cell lung cancer (35), and simultaneously participates in lipid metabolic reprogramming to provide energy and material basis for tumor cell proliferation; in addition, it can also involve in the remodeling of the tumor immune microenvironment by promoting the nuclear translocation of key molecules in the nuclear factor-κB (NF-κB) pathway (36).