PRR11 showed no significant difference and inconsistent expression across datasets, attributed to population heterogeneity (samples from the US, France, Guangdong, China), limited sample size (20 pairs insufficient for accurate characterization), detection platform differences (NGS, gene chip, RT-qPCR), and weak correlation between its CRC protein level and prognosis. The gene discussed is PRR11; the disease is colorectal carcinoma.