Further adjustment in Model 3 for age, COPD, AST, ALT, and hemoglobin preserved the statistical significance of the associations (low-TyG: HR = 1.88, 95%CI: 1.19–2.97; high-TyG: HR = 1.37, 95%CI: 1.01–1.89; all P < 0.05). The gene discussed is GPT; the disease is chronic obstructive pulmonary disease.