RETN and obesity due to melanocortin 4 receptor deficiency: This supports the hypothesis proposed by Kantarci et al. that periodontal therapy alone may not fully counteract the inflammatory burden in individuals with obesity, and a more comprehensive management, including weight reduction and systemic health monitoring, may be required to achieve optimal outcomes [27]. Our findings contrast with those of Suresh et al., who reported greater reduction in serum resistin levels in normal-weight individuals [26].