Antibiotics (1–32 mg L−1 DNase I) significantly increased the drug sensitivity of MDR K. pneumoniae biofilms, and in an animal model, catheter-associated biofilm infection was mostly eliminated.99 In a rabbit model of pleural empyema, intrapleural DNase I reduced early biofilm development, lowering bacterial aggregation, matrix formation, and biofilm mass. The gene discussed is DNASE1; the disease is pleural empyema.