For example, the long terminal repeat retrotransposons are elevated in TDP43 pathologies (Douville et al., 2011); and tauopathies, including Alzheimer’s disease, are thought to drive neurodegeneration by activating retrotransposons (Guo et al., 2018; Ochoa et al., 2023; Ramirez et al., 2022; Sun et al., 2018). Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.