IL1B and obesity due to melanocortin 4 receptor deficiency: Figure 4 shows the results of the analysis of the ratio between the serum levels of the pro-inflammatory cytokines IL-1β (Figure 4A), IL-6 (Figure 4B), IFN-γ (Figure 4C) and TNF-α (Figure 4D) and the anti-inflammatory cytokine IL-10 in the participating volunteers (older men and older women), who were separated not only into G1 and G2 groups, but also according to BMI values in normal weight (N) and with obesity (O).