In summary, this study supports the Cardiometabolic Index as a simple, accessible tool that integrates not only central adiposity, dyslipidemia, and cardiometabolic risk, but also the low-grade inflammation in older adults, while revealing a mechanistic framework in which CMI could also reflect the systemic inflammatory status, particularly that involved in the (un)balance between pro-inflammatory cytokine and IL-10–mediated counter-regulation. Here, IL10 is linked to metabolic syndrome.