TNF and obesity due to melanocortin 4 receptor deficiency: Besides these evidences, whereas the older women group with obesity showed that tha regression models were weaker, the broader set of findings in this study, respresented by higher mean levels of IL-1β, IL-6, IFN-γ and TNF-α, increased IL-1β/IL-10 and IFN-γ/IL-10 ratios, and stronger correlations between CMI and pro-inflammatory markers, consistently points to a cardiometabolic environment in which excess adiposity may amplify both inflammasome activation and Th1-type responses.