Of note, in the older women subgroup with normal weight and lower CMI, IL-1β and TNF-α tended to remain in the final models, with borderline p-values, which can suggest that, even in the absence of obesity, a subtle activation of inflammasome-related and also TNF-α–mediated pathways can already be present in cardiometabolic burden conditions. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.