Figure 3 shows the results of the evaluation of serum levels of the cytokines IL-1β (Figure 3A), IL-6 (Figure 3B), IL-10 (Figure 3C), IFN-γ (Figure 3D) and TNF-α (Figure 3E) in the participating volunteers (older men and older women), who were separated not only into G1 and G2 groups, but also into normal weight (N) and with obesity (O) according to BMI values. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.