Hypertension leads to increased endothelial permeability and BBB disruption, which has been shown in several experimental models of hypertension, including: SHR (Tagami et al., 1991; Ueno et al., 2004), Dahl-salt sensitive rats (Pelisch et al., 2011; Maeda et al., 2021), the two-kidney two-clip model of hypertension (Mohammadi and Dehghani, 2014), and angiotensin II-induced hypertension (Vital et al., 2010; Santisteban et al., 2020). The gene discussed is AGT; the disease is hypertensive disorder.