FKBP51 contributes to Alzheimer’s disease (AD) progression through its age-dependent upregulation, direct interactions with core pathological proteins, and modulation of stress-related signaling pathways (Blair et al., 2013; Jinwal et al., 2010; Roe et al., 2023). Here, FKBP4 is linked to early-onset autosomal dominant Alzheimer disease.