Mutations in ATP8B1 (PFIC1/FIC1 deficiency) and ABCB11 (PFIC2/BSEP deficiency) may cause either BRIC1/BRIC2 or progressive cholestasis with severe pruritus (Baker et al., 2019; Hassan and Hertel, 2022). The gene discussed is ABCB11; the disease is cholestasis.