MAPT and Alzheimer disease: These challenges underscore the need for alternative therapeutic strategies, such as cannabinoids, which have shown potential in modulating neuroinflammation, oxidative stress, and Aβ- and tau-mediated neuronal toxicity, positioning them as promising multi-target agents in AD management (d‘Errico and Meyer-Luehmann, 2020; DeTure and Dickson, 2019; Halawani et al., 2010; Rohn and Head, 2009; Yankner et al., 1989).