A specific example is XIST-mediated sequestration of miR-29c in glioma, leading to increased expression of oncogenic targets such as transcription factor specificity protein 1 (SP1) and O6-methylguanine-DNA methytransferase (MGMT) and promoting tumor progression and chemoresistance (Du et al., 2017). This evidence concerns the gene MGMT and central nervous system cancer.