Similar to how natural compounds like Rebeccamycin are thought to exert anti-cancer effects by modulating the PI3K/AKT signaling pathway, JadeAging may potentially achieve its anti-aging and antioxidant effects through the modulation of the insulin/IGF-1 and TOR pathways (Malek-Esfandiari et al., 2023). The gene discussed is RORC; the disease is cancer.