SLC22A12 and hyperuricemia: Research indicates that H. acerba inhibits XOD activity to reduce uric acid production; upregulates ABCG2 and OAT1 expression to promote uric acid excretion; downregulates URAT1 and GLUT9 expression to inhibit uric acid reabsorption; and modulates hyperuricemia-related inflammatory genes such as ATF3 and CXCR4.