The renin-angiotensin system (RAS) is dysregulated in various pathological conditions, including DKD and is marked by elevated levels of angiotensin II (Ang II), which contributes to kidney injury via various pathogenic mechanisms, including inflammation, fibrosis, and hemodynamic disturbances (Long et al., 2004; Xu et al., 2017). This evidence concerns the gene REN and diabetic kidney disease.