This suggests that Arg-2 plays a crucial role in the development of proteinuria, and several studies have suggested that inhibition of Arg-2 could be an attractive and appealing approach to preventing DKD (You et al., 2015; Xiong et al., 2017; Morris et al., 2011; Raup-Konsavage et al., 2017). The gene discussed is ARG2; the disease is diabetic kidney disease.