POMC and hypertensive disorder: Fusion of an unequal crossing over of highly homologous CYP11B2 and CYP11B1, and formed chimeric gene duplications, resulting in ectopic expression of CYP11B2 in ZF under the regulation of ACTH. Presents with elevated production of hybrid steroids (18-hydroxycortisol and 18-oxocortisol) measured in urine (90).Severe hypertension (>180/120 mmHg) was usually found in subjects with young onset of hypertension (age <15 years old) and was more frequently in male patients (91). A glucocorticoid, which suppresses ACTH and inhibits aldosterone production, is given to remit PA (92).