Mutation in the G-protein-activated inward rectifier potassium channel GIRK4 leads to loss of ZG membrane potential and increase in influx of Na+ into the cell, thus triggering overexpression of CYP11B2 and aldosterone overproduction (97). Presents with elevated production of 18-hydroxycortisol and 18-oxocortisol (98, 99).Early-onset severe hypertension in childhood, before age 10 years old. Presents with ZF hyperplasia and ZG atrophy. Non-suppressive aldosterone with glucocorticoid treatment, achieved complete cure after adrenalectomy (98). The gene discussed is KCNJ5; the disease is Hypertension.