CYP11B2 and primary aldosteronism: Mutation in the α1 subunit of the L-type voltage-gated calcium channel Cav1.3, activating Ca2+ at reduced depolarization potentials, leading to increased Ca2+ influx and overexpression of CYP11B2 (67).Early onset, at birth, or usually before age 10 years old. Featuring neuromuscular abnormalities (PASNA—Primary Aldosteronism associated with Seizures and Neurologic Abnormalities) (67).