Mutation in voltage-gated calcium channel (Cav3.2) leads to ZG membrane depolarization, increased intracellular Ca2+ influx, and thus increased aldosterone production (100).Early-onset severe hypertension in childhood, before age 10 years old. Incomplete penetrance, heterogeneity in phenotype expression with some asymptomatic patients (100).. Presents with other clinical features: neurologic abnormalities, epilepsy (101), autism (102), and chronic pain (103). This evidence concerns the gene CACNA1H and hypertensive disorder.