Additionally, an international systematic review of the literature in patients with T2D who were not using insulin reported a weighted mean difference of -0.31% in HbA1c in CGM users compared with SMBG, as well as significant reductions in glucose variation, glucose level, time below range, and time above range, and an increase in time in range and patient satisfaction (44). The gene discussed is INS; the disease is type 2 diabetes mellitus.