To investigate the association between the total bilirubin-to-prothrombin time ratio index (TBPTRI) and major chronic complications of type 2 diabetes mellitus (T2DM), including diabetic nephropathy (DN), diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and diabetic foot (DF), and to evaluate its predictive value for multiple complications. Here, F2 is linked to type 2 diabetes mellitus.