In other solid tumors, SIRT7 is highly enriched at promoters of tumor suppressor genes such as nucleoside diphosphate kinase A (NME1), and COP9 signalosome complex subunit 2 (COPS2), as well as the ribosomal protein genes, to inhibit their transcription and promote cell growth and invasion (38). Here, NME1 is linked to neoplasm.