Compared to participants without CircS, CircS patients exhibited higher CVAI, TyG, TyG-BMI, METS-IR, AIP, BMI, WC, TC, LDL-C, uric acid, and CRP levels, with a higher proportion of hypertension and diabetes, while eGDR, sleep duration, HDL-C, creatinine, and BUN were lower. The gene discussed is CRP; the disease is Hypertension.