REN and Hypertension: Elevated body mass index (BMI) and low physical activity—two pivotal metabolic determinants—exacerbate hypertension and hypertension-related renal injury by potentiating renin-angiotensin-aldosterone system (RAAS) activation, sodium retention, and chronic low-grade inflammation, thereby increasing the global burden of hypertension-related chronic kidney disease (HT-CKD).