Moreover, Liu et al. demonstrated that LBO, a degraded version of LBP, increased the abundance of beneficial bacteria (e.g., Lactobacillus, Bacteroides, Prevotella, and Akkermansia), alleviated intestinal mucosal edema and inflammatory infiltration, and reduced the serum diamine oxidase (DAO) and D-lactic acid (D-LA) content, improving the compactness of the intestine in HFD/STZ-induced diabetic mice, ultimately relieving DM symptoms (67). This evidence concerns the gene LBP and diabetes mellitus.