In 2023, research by Wu et al. (126) indicated that the hepatoprotective effects of curcumin, including the amelioration of lipid accumulation, inflammation, and endothelial dysfunction, were mediated by the inhibition of the NF-κB and PI3K/AKT/ hypoxia inducible factor-1 alpha (HIF-1α) signaling cascades. This evidence concerns the gene HIF1A and endothelial dysfunction.