Based on the HFD-induced MASLD mouse model, researchers found that both Platycodon grandiflorus and the Triterpenic acids-enriched fraction from Cyclocarya paliurus (CPT) could attenuate IR via the PI3K/AKT/GSK3β signaling pathway (10, 167). The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.