Proteins associated with tissue remodeling also showed dysregulation; higher levels of procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, and dystroglycan 1 suggest altered extracellular matrix turnover and basement membrane dynamics [38], processes already implicated in epithelial fragility and stromal biomechanical weakening in keratoconus. The gene discussed is PLOD1; the disease is keratoconus.