Urinary exosome-derived miR-145-5p was found to promote podocyte apoptosis by inhibiting Srgap2 and then activating RhoA/ROCK signaling pathway, suggesting that exosome miR-145-5p may play a role in the pathological process of DKD and serve as a non-invasive biomarker of DKD (38). The gene discussed is RHOA; the disease is diabetic kidney disease.