In our previous studies, we obtained extracellular vesicles (EVs) from the plasma of DM and DKD patients and identified that EV-derived mRNA (AEBP1) (6) and miRNAs (miRNA-615-3p and miRNA-3147) (7) could differentiate DKD from DM and were involved in disease progression. The gene discussed is AEBP1; the disease is diabetes mellitus.