In a recent study, Praktiknjo et al. (20) found that there was a concentration gradient between portal blood and peripheral blood for LPS, VWF, and factor VIII (FVIII) in decompensated cirrhotic patients treated with TIPS for ascites or variceal bleeding, which means LPS may promote endothelial injury and hypercoagulability. This evidence concerns the gene VWF and Ascites.