According to the 2006 Sydney classification criteria, the diagnosis of APS requires at least one clinical criterion and one laboratory criterion, including persistent positivity for lupus anticoagulant (LA), anticardiolipin (aCL) IgG/IgM, or anti-β2-glycoprotein I (aβ2GPI) IgG/IgM (10). The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.