After adjusting for age, sex, and comorbidities, a graded increase in mortality risk persisted across most prespecified subgroups (including sex, age, diabetes, antiretroviral therapy (ART) treatment, SOFA score, cirrhosis, septic shock, and PCP), with the high-CD4/low-TYG group as the reference (Figure 5). The gene discussed is CD4; the disease is diabetes mellitus.