MAP1LC3B and hepatocellular carcinoma: IFN-I regulates Beclin1 and microtubule-associated protein 1 light chain 3 beta (LC3B) expression via the JAK–STAT pathway, inducing autophagy in a dose-dependent manner across multiple models including hepatocellular carcinoma (129), and can influence autophagy protein stability through miRNA-mediated post-transcriptional regulation (130).