ANGPT1 and hereditary angioedema: Furthermore, exclusively AE-BK types of HAE-nC1INH, i.e. HAE-FXII and HAE-PLG, were included in the model and other mechanisms of HAE-nC1INH, i.e. AE due to vascular endothelial dysfunction (e.g. HAE caused by a mutation in the MYOF gene [HAE-MYOF] and HAE caused by mutations in the ANGPT1 gene [HAE-ANGPT]) were not considered.