In TC, significant enrichment was observed for B cells, endothelial cells, HLA-DPB1+Myeloid cells, NK cells, RGS5+Fibroblasts, S100A9+Myeloid cells, and SFRP2+Fibroblasts, whereas epithelial cells were predominantly enriched in BC (Figure 2E). This evidence concerns the gene SFRP2 and breast cancer.