ADRA2A and neoplasm: Functions: Identifies a feedforward loop where norepinephrine induces CAFs to secrete NGF, increasing sympathetic innervation and promoting tumor growth via ADRA2A/YAP and NGF/Trk/AKT pathways.Unsolved: Clinical efficacy and potential side effects of targeting this neuro-mesenchymal interaction with TRK inhibitors in patients remain unexplored.