Reduced function of GO:0003823~antigen binding, REGION: Complementarity-determining-1-, REGION: Complementarity-determining-2-, and REGION: Complementarity-determining-3-, and GO:0006955~immune response may imply altered affinity of CDRs for allergens, leading to minimal or no allergen-specific IgE production (negative sensitization) observed in non-T2 asthma. Here, IGHE is linked to asthma.