In univariate analysis, higher IgE levels, whether continuous (OR: 0.986, 95% CI: 0.983–0.989, p < 0.0001) or categorical (OR: 0.019, 95% CI: 0.010–0.035, p < 0.0001), were inversely associated with non-T2 asthma, while higher IL-2 levels (OR: 1.032, 95% CI: 1.007–1.058, p = 0.0119) were positively associated. Here, IGHE is linked to asthma.