To disentangle the contributions of allergic sensitization from T2-inflammatory status on serum total IgE levels, we next stratified all asthma patients by total serum IgE (high IgE, ≥100 IU/mL; low IgE, <100 IU/mL), generating four groups: non-T2_low IgE (n = 134), T2-high_low IgE (n = 23), non-T2_high IgE (n = 27), and T2-high_high IgE (n = 222) (Figures 2H–K). Here, IGHE is linked to asthma.