When all 406 subjects were analyzed together (non-T2, n = 161; T2-high, n = 245), the serum concentrations of the canonical T2 cytokines IL-4 and IL-9 were significantly lower in the non-T2 group than in T2-high patients (Figures 2A, B; p < 0.05 for both comparisons), whereas TNF-α was also modestly but significantly enriched in T2-high asthma (Figure 2E; p < 0.05). Here, TNF is linked to asthma.