NELFCD and obesity due to melanocortin 4 receptor deficiency: The observation that systemic Th1/Th17 cytokines segregated with non-T2 status only in children suggests that age-related factors—such as developmental immunology, infection burden, obesity, or epigenetic programming—may amplify non-T2 pathways earlier in life and become less prominent or more compartmentalized to the airways with aging (52).