In multivariate analysis, IgE, whether continuous (OR: 0.992, 95% CI: 0.988–0.995, p < 0.0001) or categorical (OR: 0.019, 95% CI: 0.009–0.041, p < 0.0001), was independently inversely associated with non-T2 asthma; IL-2 was independently positively associated, regardless of whether IgE was continuous (OR: 1.030, 95% CI: 1.003–1.057, p = 0.027) or categorical (OR: 1.029, 95% CI: 1.002–1.056, p = 0.035) (Figure 2L). The gene discussed is IGHE; the disease is asthma.