CD8A and neoplasm: Its more pronounced anti-tumour potential relied on TAMs reprogramming (rather than eradication) from pro-tumorigenic M2 into tumour-restricting M1 phenotype, which enhanced the cytotoxic CD8+ T cells response, reduced immunosuppressive cells (Tregs and MDSCs) infiltration and improved anti-tumour efficiency of PD1 blockade (74).