For CSPP1, the negatively enriched KEGG terms primarily involved mitochondrial and cytoskeletal processes, including oxidative phosphorylation and regulation of the actin cytoskeleton, alongside several canonical disease-named KEGG modules (e.g., Huntington’s disease, Parkinson’s disease, Alzheimer’s disease), which reflect shared pathway components rather than clinical disease associations. Here, CSPP1 is linked to early-onset autosomal dominant Alzheimer disease.