A total of 12 genes (i.e., ARHGAP32, EXOC4, ABCA3, MEGF6, ATG2A, AMZ1, SCN4A, CHORDC1, TNS1, ARHGEF11, USP10, and MAP3K5) met the threshold of FDR < 0.05 and displayed directionally consistent changes across the clinical spectrum from mild to severe AP (Figure 9). The gene discussed is TNS1; the disease is alkaline phosphatase measurement.