Among the identified five distinct macrophage subpopulations (FCN1+Inflam-Mac, PRDX1+LA-Mac, HERPUD1+LA-Mac, ALOX5AP+LA-Mac and OxP-Mac), OxP-Mac predominantly enriched in normal kidney tissues, whereas the other subtypes were mainly found in tumor regions. Here, PRDX1 is linked to neoplasm.