The activation of epithelial mesenchymal transformation (EMT) and mitotic spindle pathways suggests that the tumor cells in high-risk samples have stronger metastasis ability that may drive aggressive phenotypes through EMT-related transcription factors (such as SNAI1 and ZEB1), along with abnormal mitotic processes that may lead to increased genomic instability (27, 33). The gene discussed is ZEB1; the disease is neoplasm.