NFKB1 and autoimmune polyendocrinopathy: As shown in Figure 4, treatment of platelets with the IgG fractions from thrombotic APS induced a significant increase of phospho-ERK (Figure 4A), phospho-p38 (Figure 4B) and phospho-NF-κB-p65 (Figure 4C) expression, as compared to control untreated platelets or platelets treated with normal IgG fractions.