To evaluate the tumor growth inhibitory potential of B1451, we established an H_αvβ3 A375 xenograft model in severely immunodeficient mice (Balb/c-Null for DNA Damage-Growth factor Attenuated Background, Beta-2 Microglobulin Knockout mouse, B-NDG B2m KO mice) mice (n=5). Here, B2M is linked to neoplasm.