Kaplan-Meier survival analysis based on three independent HCC cohorts (TCGA, GSE14520, and HCCDB18) revealed that patients with high RDH16 expression had significantly better overall survival compared to those with low expression in the TCGA (p = 0.0022) and GSE14520 (p = 0.016) cohorts. The gene discussed is RDH16; the disease is hepatocellular carcinoma.