IL1B and neoplasm: Additionally, analysis of preoperative biomarkers revealed a significant negative correlation between interleukin-1β (IL-1β) and TRG (ρ = –0.75, p = 0.013; τ = –0.60, p = 0.027) (Figures 4C, D), indicating that higher preoperative IL-1β levels tended to be associated with better tumor regression.