To identify the crucial epigenetic markers in HOXB family in AML, we first analyzed the prognostic value of HOXB members methylation with available data (HOXB2/HOXB3/HOXB4/HOXB5/HOXB6/HOXB7/HOXB8/HOXB9) using TCGA databases. This evidence concerns the gene HOXB6 and acute myeloid leukemia.