In total AML patients, hypo-methylation of HOXB3, HOXB5 and HOXB6 was markedly correlated with shorter OS (P = 0.006, 0.004 and 0.011, respectively) and DFS (P = 0.005, 0.005, and 0.009, respectively), whereas the other members did not affect survival (both P>0.05, Figure 1a). The gene discussed is HOXB5; the disease is acute myeloid leukemia.