MAPT and psychotic disorder: In a subset analysis excluding participants with psychosis at baseline, psychosis was significantly associated with a faster increase in CSF t-tau level (β = 0.372, p = 0.028), whereas the associations with longitudinal changes in CSF Aβ1-42 level (β = −0.123, p = 0.317) and p-tau181 level (β = 0.007, p = 0.947) were not significant (Supplementary Table 5).