Amongst other genetic variants, Gjb2 and Gjb6, which encode connexin 26 (Cx26) and connexin 30 (Cx30), respectively, are responsible for DFNB1, the principal cause of non-syndromic hearing loss in the Mediterranean population (Fetoni et al., 2018; Paciello et al., 2022; Xu et al., 2023). This evidence concerns the gene GJB2 and hearing loss disorder.