This cognitive deficit is related to specific changes in the expression of signaling molecules associated with cognition, particularly the BDNF factor, the 2B subunit of the N-methyl-D-aspartate (NMDA) receptor, the serotonin transporter, and the neuropeptide Y system, in various brain regions (Fröhlich et al., 2016b). The gene discussed is BDNF; the disease is Cognitive impairment.