Leech extract has been shown to inhibit THR-induced tissue factor (TF) expression in vascular endothelial cells (VECs) and counteract THR's suppression of tissue factor pathway inhibitor (TFPI) release (Guofeng et al., 2017),linking these effects to its observed anticoagulant and antithrombotic properties and underscoring its potential significance in the prevention of cardiovascular and cerebrovascular diseases. This evidence concerns the gene TFPI and cerebrovascular disorder.