MAPT and Alzheimer disease: The hallmark pathological features of AD include the accumulation of β-amyloid (Aβ) peptides forming senile plaques and hyperphosphorylated tau aggregating into neurofibrillary tangles (NFTs), accompanied by synaptic dysfunction, neuronal loss, and chronic neuroinflammation (Agostinho et al., 2010; Winblad et al., 2016).